An Urban's Rural View

The Puzzle in FDA's Curb on Animal Antibiotics

Urban C Lehner
By  Urban C Lehner , Editor Emeritus
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It's easy to understand why the Food and Drug Administration wants to limit the use of antibiotics in animal agriculture. Antibiotic resistance is a frightening problem. It kills 23,000 Americans a year. Without effective antibiotics "cured" diseases become uncured; hip replacements and organ transplants are too dangerous to contemplate; simple infections turn life threatening. So dire are the consequences that it's natural for FDA to want to curb every possible abuse and overuse of antibiotics.

It's also easy to understand why animal agriculture, while promising cooperation with the new FDA rules, continues to feel picked on. The antibiotics used for animals are, as livestock groups say, mostly different from those used for humans. Even the Centers for Disease Control and Prevention, as concerned as it is about the use of antibiotics in animals, says most antibiotic infections come from hospitals and nursing homes. Yet there's so much focus on the possibility of resistance from eating meat and so little on doctors who over-prescribe antibiotics and patients who don't finish their courses.

What isn't easy to understand is how the manufacturers of animal antibiotics can say two seemingly contradictory things: that they expect everyone to cooperate with FDA, and that they don't see the new rules hurting their sales.

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Here are two possible solutions to this puzzle. If you have others I'd love to hear them.

-- Animal ag's critics are wrong: Livestock raisers aren't overusing antibiotics now and thus will have little cutting back to do. Contrary to what the critics think, producers only use them now to cure disease, or to prevent disease in situations where disease is a clear and present danger.

-- The critics are right: FDA's new rules are riddled with loopholes, and not just because they're voluntary. One big loophole is allowing antibiotics to be used for "preventing" disease, even under a veterinarian's supervision. As long as animals are raised in crowded conditions, as many are today, there will always be a danger of disease, and thus a justification for antibiotic use.

Neither explanation satisfies. The first seems contrary to fact. There's little doubt that at least some animals are being given small doses of antibiotics to promote growth, which is a big part of what the FDA wants stopped. If this use stops, sales will fall.

The second seems too sweeping. Granted, some preventive uses meet the standard of medical necessity: When the animals at a neighbor's operation have a communicable disease your animals are at risk no matter how much space you give them. Other preventive uses, though, are to prevent diseases that are remote or even theoretical. Those uses would end if everyone's playing by the FDA's new rules, and sales will be affected.

Yes, growth in our animal herds might offset the impact, but that's not the same as saying, as one manufacturer did, that the new rules aren't a material event.

A final thing that's hard to understand is how requiring a veterinarian to sign off on antibiotic usage will work in a country with a shortage of large-animal vets. In some states the few vets around are stretched thin with too much work. Sometimes they're a hundred or more miles down the road. Who is going to do all this supervising?

Livestock guys: Educate me, please.

Urban Lehner can be reached at urbanity@hotmail.com

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Comments

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Urban Lehner
12/18/2013 | 1:13 PM CST
Marc Rasmussen emailed me the following comment: "A few points to suggest for you to consider in your understanding of the situation. 1. Just because ag uses different antibiotics than the human area this is not a free pass for ag to do nothing. Bacteria can still become resistant through a process called cross resistance. Poke a bacteria with one antibiotic and you switch on defense and resistance responses for a whole suite of resistance genes for other antibiotics. Prominent ag spokepersons on this topic tend to not mention this cross resistance interrelationship. They conveniently seem to skip over this fact. Heavy metal exposure and other stressors of bacteria can also turn on the same resistance genes in bacteria as does antibacterial exposure. This is why FDA also announced this week it going to start cracking down on triclosan and other antibacterials in soap and even in toothpaste. All of these things prompt bacteria to be on the defensive and switch on resistance mechanisms. 2. Other things to remember about the resistance problem. From a bacteria's perspective remember "that which does not kill me makes me stronger" 3. Also think of the problem as a mixing bowl. We dump a global mix of animals, manure, humans, antibiotics, antibacterials and bacteria in the bowl. We cannot predict with precision who survives and what crawls out of the bowl. Often times it is resistant bacteria and increasingly bacteria that are resistant to a whole range of antibiotics. Some of the worst that we are finding especially in other parts of the world cannot be killed with any drug. Some TB strains and some gram negatives for example. So we see G- urinary tract infections with the potential to kill. We also have a real problems with Clostridium difficile in the US which is a real killer of senior citizens in nursing homes and hospitals. Pediatric doctors are also seeing a rise in C diff in teenagers with some fatalities. Since this bug is a spore former once a premise is contaminated it pretty much stays contaminated and waits for the next occupant to move in. 4. Livestock ag needs to do its part as do other users in the medical world, ethanol plants and even soap manufacturers. Loose voluntary rules that allow the status quo in the livestock industry only give the appearance of doing something when in fact it does not contribute to the overall solution. We need to quit throwing so much drug into the mixing bowl if we hope to slow the resistance problems that crawl out of the bowl."
Urban Lehner
12/17/2013 | 6:06 PM CST
Over at the Harrington Sort and Cull blog, where the editors also placed this post of mine because John is on vacation, Tom Trick commented as follows: "If unit cost for antibiotics goes up in proportion to potential reduction in usage, its a net zero for drug suppliers. Hmmmm, maybe there should be "raised with/without the use of antibiotics" label requirement and let the consumer decide with their wallet if antibiotic resistance is a concern?"
Urban Lehner
12/17/2013 | 7:46 AM CST
Here's a comment I've received from a producer. Good thoughts, all. I welcome more. "Here goes -- At first glance anyway -- This claim is by the makers of the antibiotics who just may recognize that restricted use of antibiotics as a preventative to disease (the wish of FDA) will result in heavier doses required to treat the disease after the animals become ill. No longer is an ounce of prevention worth a pound of cure. OR, maybe your first solution may be close to accurate as it is on this farm, we lose as much as 2% of our production during the last 30-60 days before slaughter in order to comply with withdrawal protocol; Your last concern in this day of instant communication, might be the vet's confidence in relying on the expertise of the animal's caregiver (Livestock farmer) for him (the vet) to prescribe antibiotics from some distance."